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PROTO-ONCOGENE PROTEINS C-KIT
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DeCS
Descriptor
English
:
Proto-Oncogene Proteins c-kit
Descriptor
Spanish
:
Proteínas Proto-Oncogénicas c-kit
Descriptor
Portuguese
:
Proteínas Proto-Oncogênicas c-kit
Synonyms
English
:
Antigens, CD117
CD117 Antigens
Receptor, Stem Cell Factor
Stem Cell Factor Receptor
c-kit Protein
c-kit Receptor
kit Proto-Oncogene Protein
p145(c-kit)
Tree Number:
D08.811.913.696.620.682.725.400.050
D12.776.543.750.060.124
D12.776.543.750.705.852.150.100
D12.776.543.750.750.400.200.170
D12.776.624.664.700.183
D23.050.301.264.035.590
D23.101.100.110.590
Definition
English
:
A protein-tyrosine kinase receptor that is specific for
STEM CELL FACTOR
. This interaction is crucial for the development of hematopoietic, gonadal, and pigment
stem cells
. Genetic mutations that disrupt the expression of
PROTO-ONCOGENE PROTEINS C-KIT
are associated with
PIEBALDISM
, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with
tumorigenesis.
See Related
English
:
Piebaldism
History Note
English
:
2000(1996); use PROTO-ONCOGENE PROTEIN c-KIT (NM) 1989-1995
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
32639
Unique Identifier:
D019009
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS